Jim Cummings provided the narration in most episodes. The titles of the episodes are completely unrelated to their contents but rather (usually) over the top titles always using the word 'dark' or 'darkness' and often with the words 'black' and 'night' (e.g., The Phantom Mask of the Dark Black Darkness of Black, Return of the Night of Blacker Darkness, Return of the Dark Mask of Phantom Blackness, etc.).
It was stated in the first episode that Pith Possum was an ordinary lab opossum until he gained ultra opossum-like abilities upon an experiment gone wrong. Pith Possum (even when in his true identity) also has developed a crush on a female human reporter named Doris Deer (voiced by April Winchell) who mostly loves Pith Possum more than his true identity. Pith Possum fights various enemies with his recurring one being a mad lumberjack named Dr. Pith Possum's true identity is lowly tabloid copyboy Peter Possum. Pith Possum: Super Dynamic Possum of Tomorrow Ī spoof of the Batman comics, with the superhero Pith Possum (voiced by Jeff Bennett) and his sidekick Obediah the Wonder Raccoon (voiced by Patric Zimmerman) fighting crime in Possum City when called by the gorilla Commissioner Stress (voiced by Brad Garrett) and the monkey Lieutenant Tension (voiced by Jess Harnell). Husband is always referring to their home as their " domicile" before the two leave their pets in charge while they are away. Their owners are unseen stock characters only viewed from the neck down and named (appropriately enough) Husband & Wife (voiced by Steve Mackall and Tress MacNeille). This segment involves a cat named Shnookums (voiced by Tristan Dove) and a dog named Meat (voiced by Frank Welker) who do not get along very well.
This animated series actually follows three segment series.